2022.01.17 17:16 howdoufeelaboutsnail Are these too big for my face?
2022.01.17 17:16 Pxpercutt Sheck Wes "WiNDMiLL" type beat
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2022.01.17 17:16 PuzzleheadedWave922 Sheyla Mell (@eusheylamell) OnlyFans MEGA Link XXX Updated Jan 2022
2022.01.17 17:16 randomname_24 Will Russia cause WW3 over Ukraine within the next few months?
2022.01.17 17:16 namelessundead Hacked or Cracked? - Halo Infinite
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2022.01.17 17:16 Armed_AcidRain Hanging out with the ultimates collab
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2022.01.17 17:16 dikthecat Shropshire Union Canal Llangollen Branch and Whixall Moss
2022.01.17 17:16 AmaranthAetherion Any good Skyrim playthroughs on YouTube with multiple player characters?
I'm looking for examples on YouTube of people playing multiple characters in a single shared continuity, either by using a mod like Project Proteus or just stating they share the same timeline of events. I'm thinking of doing an "MCU style" playthrough using multiple characters myself and would like to see how this actually looks in practice.
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2022.01.17 17:16 postmastern Биологи выяснили, как нарушение циркадных ритмов вредит сердцу
| Ученые выяснили, как именно нарушение циркадных ритмов приводит к заболеваниям сердца. Соответствующая статья была опубликована в журнале Circulation.|
Циркадными ритмами называют циклические колебания интенсивности биологических процессов в организме, связанными со сменой дня и ночи. Иными словами, это биологические часы организма, и нарушение их работы может вызывать разные проблемы со здоровьем.
Ученые из американского Медицинского Колледжа Бейлора исследовали, как нарушение циркадного ритма приводит к заболеваниям сердца, что врачи замечали давно. Выяснилось, что ключевую роль в этом играет белок Rev-erbα/β, основной регулятор циркадного ритма.
«Мы изучили, как Rev-erbα/β влияет на метаболизм сердца, нокаутируя ген, который отвечает за его производство, в кардиомиоцитах мыши, – говорит Чжэн Сунь, один из авторов исследования. – Отсутствие этого гена привело к повреждениям сердца». Затем исследователи изучили метаболизм организма во время сна и бодрствования, и выяснили, что Rev-erbα/β в основном вырабатывается в часы сна.
Сердце по-разному реагирует на различные источники энергии в зависимости от времени суток. В фазе покоя, которая у человека приходится на ночь, а у мышей на день, сердце использует в качестве основного источника энергии жирные кислоты, а в фазе бодрствования сердце более резистентно к углеводам. «Мы обнаружили, что без Rev-erbα/β в сердце возникают метаболические дефекты, которые ограничивают использование жирных кислот во время отдыха и приводят к чрезмерному использованию сахаров в период активности», – говорят авторы.
В целом, заключают ученые, основной урон сердцу при нарушении циркадных ритмов наносит метаболический дефект, который не дает клеткам использовать жирные кислоты.
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2022.01.17 17:16 Garrusikeaborn98 Owning xbox in unsuported country
Hey everyone. In a day or two my series S will be here so I'm wondering, since I'm from Croatia and its not under supported countries yet.....what's the best region to set my account location as? I plan on buying games from CDkeys. If it says that it only works for example in UK and I set my account as UK...will it work in my country? Please someone clarify this for me, It's the only thing bugging me honestly.
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2022.01.17 17:16 PosterBoy1017 Anybody else really confused right now with whether to buy or wait?
Prices are skyrocketing right now. It’s one of those things where I’m hesitant to buy. But I know even if there is a crash soon it will pay off. My purchase choices are between Wonder Woman, SBW common, or the grail comics. What do you guys think? Should I wait it out?
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2022.01.17 17:16 ChaiHai Is there a way to refresh quest options?
I'm at the point where I'm grinding to be able to open the 72 door. There are certain ones I won't do.
I don't see why we have to wait one full day for them to reset. D: If I want to take the time to get em all done in one setting, let me!
Making it so I know I won't be able to proceed until I do tedious quests is one thing, but making it impossible to grind out in one day is another.
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2022.01.17 17:16 swarmack3 @NeilDalal96: With Pat Delany in health and safety protocols, assistant coach Zach Guthrie has taken over the duties of watching film with Deni Avdija and warming him up pre-game
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2022.01.17 17:16 Project-Zen Need help with date ideas Please Help
Hello everyone this is my first post ! So I hope I can get a lot of support and help here
Long story short I met this girl at my gym and I pulled up my big boy pants a decided to ask her out ! She said yes and we went on our first date yesterday and it was fantastic ! Picked her up around 2pm and we went ice skating and got some grub and then sat down at the mall talking the entire time until the mall closed (we lost track of time ) from what I gathered she had tons of fun since it was her first time ice skating and she learned everything so quickly and by the time I dropped her off at home it was 11:30 which was not planned but amazing how we managed to have conversation and not get bored for 9 hours !
My only issue is idk where to take her for the second date I have very little experience going on dates but I want to do something fun where we can interact with each other a lot so we can get know each other more and so we can both make a more knowledge decision about next steps for when I ask her to be more serious with me
She’s 24 and I’m 25 She doesn’t drink or smoke ! We are both active people (athletic type )
Any advice helps ! Literally any advice not just date ideas 😊😊
we live in the North Jersey area if anyone knows any particular places there
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2022.01.17 17:16 steveadrehel Bigfoot Tracks With Toes
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2022.01.17 17:16 ChewbaccaHasADogDick Left somebody out while I shoveled snow for a few hours and she broke my heart. Luckily this is the only piece of the 75277 set she decided to destroy smh
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2022.01.17 17:16 arilione North California, west facing, mild winter. no idea what the wood chips are. can anybody I d. these shroomies?
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2022.01.17 17:16 thatdude-again Vexana Changes That Could be Taken into Consideration
Based on my popular comment, I've decided to take this idea a step further. I've given myself some time to think about it carefully and I'm satisfied with what I've created.
I just hope devs get to see this. Even though I'm not anywhere near good at balancing a game, I don't think all the ideas presented here are completely garbage and believe some of them could be implemented.
The Idea Cursed Oath - Continuously deals damage to one hero over the course of 12 seconds. While burning, the hero will have all sources of healing reduced by 30% (includes mana and energy regen).
Tap again to convert DOT into a single burst of damage equal to the remaining ticks of damage.
After 12 seconds, you'll gain the ability to summon an unit whenever you want for 12 seconds. The unit must be manually summoned (similar to Valentina's ult, you can keep your "sample" for as long as you want). If you chose to deal the damage all at once, your puppet will be immediately summoned.
If not immediately summoned, your ult will be replaced with your current stored puppet and will not enter CD until you use it.
Once the unit is summoned, instead of having the usual "I summon you here" skill, the ult will be replaced with a skill depending on what kind of hero you used your ult on.
Tank or Tanky Fighters - you summon a golem that inherits a portion of your target's HP+some of your magic power as HP.
Your ult will be replaced with a target-locked skill that's similar to "Unstoppable Force" (CD 8 secs), forcing your puppet to dash towards one nearby enemy and knocking back everyone nearby.
Upon successfully hitting "Charmed Specter", the puppet will jump to the designated direction and knock all enemies airborne similar to "Avatar of the Guardian".
Bursty Marksmans and Mages - you summon a knight that inherits 100% of your HP + some of your magic power as HP. It's damage scales really well with your magic power.
Your ult will be replaced with a target-locked skill that's similar to "So-Called Teamwork" (CD 4 secs), commanding your puppet to blast your foes with a heatwave dealing damage and slow.
Upon successfully hitting "Charmed Specter", the puppet jump at its target, increasing its attack speed and slowing the target.
Mobile Assassins and Supports - you summon a wyrm that inherits 100% of your HP. It's damage scales incredibly well with your physical and magic powers.
Your ult will be replaced with a target-locked skill that's similar to "Defiant Sword" (CD 2 secs), quickly closing the gaps and dealing damage to the lowest HP enemy nearby.
Upon successfully hitting "Charmed Specter", the puppet will smash the ground with incredible force, immobilizing nearby units similar to "Falling Starmoon".
Conclusion • Why this change is good? - She poses an actual threat to heroes that rely on energy, putting them on a risky spot if they're caught in her ultimate. It'll also benefit as a counter to spellvamp heroes.
People can still play her as a burst combo mage due to it's insta-burst feature. It's especially effective to secure kills long-range.
These changes would make Vexana a top tier mage that can fit any lineup.
My only concern is that it's probably too much to cram into a single skill. I think the best way to deal with this is similar to what they've done with Thamuz, implementing some of his traits into his passive instead of cramming it all on his 1st skill.
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2022.01.17 17:16 aysgamer hey fellows, any tips on dealing with heartbreak? ty
2022.01.17 17:16 Emotional_Storm5923 Todd Segway
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2022.01.17 17:16 MalcolmXfiles Low level beef with the Weinstein bros
2022.01.17 17:16 Socialasshat420 Can I get help identifying this substance?
2022.01.17 17:16 PutSame8550 Join the Hoes Galore 2.0ð Discord Server! (Never Expires)
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2022.01.17 17:16 ml16519 Why don’t Morgan and Ladarius follow each other on social media?
I just noticed Ladarius and Morgan don’t follow each other on social media. She’s in several promotional pictures he’s posted but not even tagged. Then I noticed they don’t follow each other. So they may even have each other blocked. Anyone know why? I haven’t heard him say anything about her or vice versa really.
They both seem to follow everyone else.
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2022.01.17 17:16 OkBuyer1271 Should parents be jailed for denying their child’s sexual orientation or gender identity?